Thyroiodinum.
Iodothyrinum. Trituration.
Clinical.─
Goître. Obesity. Urine, increase of.
Characteristics.─
Thyroiodine
is now more generally named Iodothyrine, but I retain
the former as more convenient. Hoenigschmied (Aerz. Cent. Zeit.,
No. 6, 1900, quoted A. H., xxvii. 211) says of it that
it is present in only small quantities in the thyroid of the sheep. It is completely free
from albuminous substances, stable, and directly assimilated. The iodine exists in organic
combination, and Thyri. contains 0.003 parts of Iodine to every gramme. The general effects of the drug are─increased
secretion of urine and corresponding loss of flesh. Hśnigschmied gives two cases: (1) Labourer, 42, for several years had enlargement and induration
of all lobes of thyroid, the enlargement causing compression of the structures of the neck,
dyspnśa, whistling respiration, hoarseness, short, dry cough, vertigo. Thyri., 5-grain tablets, one every evening; at the end of a week
twice daily. After using twenty-five tablets the gland was smaller and softer; the
previously hard and resistant nodules were elastic; after two more weeks only remnants of
the goître remained. (2) Man, 60, thyroid enlarged in
all its lobes with a glandular cystic swelling in the right one; dyspnśa, loud whistling
breathing. Two, three, and at last four tablets were given daily for two months, by which
time the goître had vanished, but the cyst was not changed. (3)
Man, 45, medium height, sedentary, suffered from obesity, vertigo, dyspnśa, weariness.
Pulse feeble, 76; functions normal; appetite and sleep good; weight 230 pounds. With
increasing doses of Thyri., up to ten tablets daily, the
weight steadily went down to 160 pounds, activity increasing in proportion. When the dose
had reached four tablets daily the urine became very abundant, but was free from albumen.
The daily dose was increased one tablet every four days. At one stage Fowler’s solution of
arsenic, four drops in wine, was given as well to prevent Thyroidism.
Relations.─
Antidoted by:
Ars. Compare: Thyr. Urine, Urea.® 2000
Article