SOLANINUM.
An alkaloid, C43H69NO16, obtained from Solanums, especially from S. nigrum
and S. dulcamara.
Preparation
, Triturations.
Authorities.
Reil’s Journ. f.
Pharmacodynam., 1857. 1, Dr. Clarus,
took 1/2 grain of the acetate first day, 1 grain second day, 6 1/2
grains third day; 2, Schroff,
Lehrbuch f. Pharm., 4th ed., p. 623, proving of Solanin from S.
dulcamara on four persons; 3,
Froumüller, Klin. Studien, etc., gave to several persons doses of 1 to
4 grains of S. from S. tuberosum and nigrum, no symptoms; afterwards
took 6 grains; 3a, same, persons took 15 grains.
MIND.
►
Stupefaction without previous excitement, [2].
HEAD.
►
Vertigo, [2], [3a]. ► Head
hot, heavy, dull painful, [2]. ► Heaviness of the head, [1]. ► Pain in
the occiput, [1].
EYE.
►
The pupils were not much affected, perhaps somewhat contracted, [1].
MOUTH.
►
Salivation, [2]. ► The pure alkaloid has a cooling, acid,
and salt taste, and when chewed, it causes a glutinous sensation in the
pharynx and throat, with scraping, which extends down to the stomach,
where it becomes a peculiar sticking pain, [2]. ► Bitter
taste, [3].
THROAT.
[10.]
► Scraping in the throat, [1], [2],
[3a].
STOMACH.
►
Constant eructations, [2]. ► Nausea and diarrhœa, [3a]. ►
Nausea, and violent ineffectual efforts to vomit, [2]. ► Nausea
and vomiting, [3]. ► About 5 P.M., vomiting three times
without previous nausea, without pain and without any intestinal
symptoms, [1].
ABDOMEN.
►
Rumbling in the abdomen, [2].
URINARY ORGANS.
►
(The next morning, examination of the urine showed albumen!), [1].
RESPIRATORY ORGANS.
►
Hoarseness, [2]. ► Respiration slightly slower than natural,
temperature not affected, [3a]. [20.] ►
Very superficial slow respiration, 15 or 16 to 14 to the minute, [1]. ►
Difficult respiration, with oppression of the chest, [2]. ►
Oppressed respiration, [1].
PULSE.
►
Pulse increased in rapidity, weak (72 to 88), [1]. ►
Increased frequency of the pulse, sometimes as much as 25 beats, lasting
four hours (the next morning, somewhat slower than natural), [2]. ►
The pulse ran up to 95 and 100, was remarkably soft, small, and weak, [1]. ►
Pulse rose from 76 to 92 in fifteen minutes; in twenty minutes more it
returned to the normal, [3a]. ► It caused after ten hours slight slowness
of the pulse and respiration, but no change in the temperature, [3]. ►
Pulse small, weak, thready, [2].
INFERIOR EXTREMITIES.
► Slight tonic spasms of the lower
extremities, [2]. [30.] ►
The next morning the prover felt quite well, with the exception of some
weakness in the lower extremities, [1].
GENERALITIES.
►
Weakness, [1]. ► Sensation of great weakness, [2]. ►
Sensitiveness to light, noise, and to touch, [1].
SKIN.
►
Skin dry, [2]. ► Hyperæsthesia of the skin; creeping
along the spine when touching the skin; more easily tickled than
natural, [2]. ► Itching of the skin, [2].
SLEEP.
►
Frequent yawning, [2]. ► Great sleepiness, with inability to
sleep, [2]. ►
Sleepiness, [2]. [40.] ►
Sleep very restless, frequently disturbed by frightful dreams, [2]. ►
Sleep frequently interrupted during the night, but without dreams, [1].
FEVER.
►
Extremities cold, [2]. ► Profuse perspiration without weakness, [1].® 2000
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