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COCA. – THE ENCYCLOPEDIA OF PURE MATERIA MEDICA By TIMOTHY F. ALLEN, A.M., M.D.

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COCA.


GENERALITIES.

► Objective.
[380.] ► Weight of
body increased one-eighth of a pound, [14]. ► Retarded metamorphosis, diminution and prevention of the
natural loss of tissues which attends every bodily effort; it lessens the waste of tissues, [34]. ► Power of muscles
notably augmented, [12]. ►
Aptitude for work increased, [12]. ► Active and vigorous the whole day (sixth day after 10 drops
of the tincture, the previous night), [3]. ► Great physical vigor and great endurance, in spite of slight
nourishment and little sleep
, [10]. ► Cerebral functions stimulated; inclination for work, and
especially for fatiguing bodily exertion; hurried and impatient movements; rapidity in
writing. Could not stay in one place, must go out, and walk or run, [43]. ► General excitement of the
nervous system, very similar to that caused by a mixture of coffee and brandy, [43]. ► Strongly excited
imagination; increased desire for bodily exercise; hand trembles, can hardly write;
trembling of legs, shiverings in back, and inability to keep still, [43]. ► Such a state of nervous
excitement that he did not repeat the experiment (substituting it for the usual Chinese
tea), [9a]. [390.]
► Unpleasant nervous excitement, so that he was unwilling
to make a second proving, [9]. ►
Indolence (twelfth day), [3]. ►
Weakness, in the afternoon (nineteenth day), [3]. ► The patient becomes weak and emaciated, [9a]. ► When jaundice occurs
indications generally follow showing the shattered condition of the nervous system; the
patient complains of headache, and other like sufferings, gets weaker, can scarcely take any
food, and quickly becomes emaciated. This state is often succeeded by a kind of leukemia;
the bilious tint gives way to a leaden color; an incurable sleeplessness sets in, [9]. ► Gait unsteady,
tottering, with trembling lips, disconnected speech, dull apathetic mood, [10]. ► Becoming old very early,
with imbecility in old age, [10]. ► Chewers finally die of general consumption, [9]. ► Œdematous swelling, and
afterwards ascites, [9a]. ►
Partial œdematous swellings arise and subsequently terminate in ascites, dropsy, death;
also pain of the limbs, which are removed in a short time by the breaking out of boils, [9]. [400.] ► Sudden jerking and waking from the usual short afternoon nap
(eighth day), [6]. ►
Endeavors to get into the open air, [22]. ► General restlessness (seventh day), [21]. ► Involuntary, rapid
walking, with the head inclined forward, with vertigo and dread of falling (transiently
relieved by bouillon), (fifth day), [3]. ► Uneasiness; blackish froth about the corners of the mouth, [10]. ► Great uneasiness,
discomfort, and loss of sleep, [9]. ► When taken in the evening it causes great uneasiness,
discomfort and sleeplessness; taken in the morning, its action is milder, causing loss of
appetite, [9]. ►
Uneasy tossing about in bed; the child repeatedly puts the arms under the head; indistinct
speech, [8]. ►
Though very sleepy, turned and twisted about all night, and awoke tired and heavy next day,
with aching shoulders, [12]. ►
Am incessantly turning about in bed; uneasy when lying on either side. Sometimes am afraid
of losing my balance, and fancy myself carried off into space. I get up and walk the room
with great strides; feel as if I could run for a long time. Am conscious all over of an
indefinable buoyancy and flexibility. In a quarter of an hour, these feelings are usually
succeeded by heaviness of the head, drowsiness, and desire for rest and quiet. I fully agree
with Rossier’s statement, that what is lacking, at this stage, is not the ability to move,
but the inclination, [43]. ►
Subjective.
[410.] ►
A kind of numbness, with a feeling of serenity, with retention of clear self-consciousness,
and an instinctive desire to make no motions, not even to move a single finger, for an
entire day. While in this condition there set in a sleep, full of strange quickly changing
dreams, which could last an entire day without leaving any feeling of lassitude or
restlessness, [22]. ►
Extraordinarily well, lively, and able to work, from morning till noon (second day), [3]. ► Peculiar sensation
of comfort, with slight pleasant warmth over the whole body, plainly starting from the
stomach, [11]. ►
Felt very buoyant on walking out in a dense chilling fog, [12].
► Great lightness while climbing a mountain, without any
respiratory troubles
, [10]. ► Felt stimulated after increased dose; constipation, slight
movement in the evening (third day); bowels not moved at all; after taking infusion several
times through the day still costive (ninth day), [30].
► A peculiar, scarcely to be described feeling of
increased strength, agility, and inclination to work, set in as the first indication of
intoxication, which nevertheless differs entirely from the exaltation produced by alcohol, [22]. ► After he got
under the influence of 4 drachms, there set in a peculiar sensation of isolation from the
outer world, and an irresistible inclination to feats of strength, so that he (who, when in
a healthy condition, carefully avoided gymnastic exercises), with a catlike lightness and
certainty sprang upon the writing-table, without throwing over the lamp or other fragile
things standing there, [22]. ►
No desire for, or skill at work (second day), [5]. ► Feel tired and weary; must exert myself to keep awake,
although not sleepy, but feel as if I wanted to shut my eyes (seventh day), [21]. [420.] ► Fearfully tired, especially on the ninth day, [7]. ► Felt weary; no inclination
to work (fifth day), [18]. ►
Weariness, with vertigo and headache, especially in the forehead and occiput, with
chilliness (fourth day), [3]. ►
Weariness in the evening, followed by sleep, less on going to bed (fifth day), [3]. ► Great weariness
(fourth day), [3]. ►
Great weariness, in the evening (seventh day), [7]. ► Uncommon weariness after a moderate walk (seventh day), [6]. ► Extreme weariness,
so that only by the greatest, exertion was he able to finish his business (third day), [3]. ► Feeling of
weakness and sleepiness, [1]. ►
After chewing the leaves, we uniformly experienced a disagreeable sensation; aversion of
food; feeling of fulness and heaviness in stomach, with dryness and even pain in throat, [25]. [430.] ► Rest indispensable to enjoy the effects of Coca; while riding
on horseback, while walking or during manual labor, the Coca had very little influence, [19]. ► When incapable
any longer of the recumbent position, seeks alleviation by the side of the glimmering fire, [9].

SKIN.

► Objective. ► In persons with a thin skin and fair complexion, hæmorrhage
will take place from the surface of the body, [9]. ► Some dark spots like ecchymoses under the skin, not elevated
or painful, the largest about the size of a pin’s head, on the contiguous sides of the first
phalanges of the ring and little finger of the right hand, not affected by any pressure or
washing. To-day I have also noticed three very minute similar spots on palm of right hand,
also two similar spots close together on the ulnar side of the palmar aspect of the first
phalanx of the left little finger, near the base, also two very small similar spots on
radial side of the second phalanx of the right little finger (sixty-fourth day); the largest
red spots were on radial side of first phalanx of right little finger; spots on palm of
right hand gone (sixty-eighth day); are on left hand, and some on right, removed by washing
(sixty-ninth day); the last rubbed off to-day (seventieth day), [16]. ► In the loose skin, between
the left thigh and scrotum posteriorly, a small lump, slightly tender on pressure, and
sometimes when walking; no external appearance (eighty-first day), less tender (eighty-fifth
day), [16]. ►
Eruptions, Dry.
► After using for a number of
days, on himself and others, there broke out a circumscribed erythema; on one an exanthema
resembling herpes, around the eyelids, [22]. ► A kind of nettlerash breaks out on several parts of the body
or is limited to the lips, and occasion scabs, bleeding and insupportable pains, [9]. ► Small pimples on
the inner surface of the thigh; they itched very much during the night, so that he was
obliged to scratch them until they bled (seventh to ninth days), [7]. ► Eruptions, Pustular.
► On right cheek, close to alæ nasi, a swelling,
scarcely painful, even to pressure; rather hard, slightly apparent to sight, resembling one
he had on the perineum, freely movable with the integuments of the part (one hundred and
thirteenth day); getting smaller next ten days, then when pressing it, a slight discharge of
pus mixed with blood, from an external hole just below it, repeating afterwards at
intervals; getting smaller, two weeks; three weeks, after, still to be seen; nearly gone in
the fifth week, [16]. ►
During the expiration, after a deep inspiration, a kind of tingling in hands, usually in
both, but not always in same place, particularly in palm of left hand; once in palm and back
of right hand, and once it seemed to go down palm of right hand towards fingers; once in
both hands, and only during the first expiration if deep inspirations were repeated; not
influenced by the position of the hands; evening and morning, while feeling very warm; when
getting cooler it disappeared, [16]. [440.] ► Itching of front of
throat (externally), not dispelled by scratching; it is a feeling of a fine rash coming out,
8 and 10 P.M. (after eight hours), [17]. ► Violent itching on the seat, at junction of right thigh
muscles with gluteus maximus; comes on again after scratching, is very sharp (first day,
2.20 P.M., after ninety minutes), [17].

SLEEP AND DREAMS.

► Sleepiness.
► Frequent yawning, [1].
► Frequent yawning, without weariness, the whole forenoon
(after 40 drops, eighth day), [6]. ► Frequent yawning and sleepiness while sitting (first day), [6]. ► Repeated yawning
after supper (one hundred and fifty-third day), [16]. ► Transient sleepiness, followed by wakefulness, lasting till 4
A.M. (fifth day after 10 drops of the tincture), [13].
► Unusual sleepiness after twelve hours dispensary work, [27]. ► Extreme
sleepiness at 5.30 P.M., could scarcely keep the eyes open long enough to write a few words,
relieved for an hour and a half after coffee (third day), [3].
► Inveterate sleepiness, [9a].
[450.] ► Sleepy at 4
P.M. (third day), [3]. ►
Sleepy very early in the evening, was, however, unable to sleep, for in bed he became wide
awake, with heat, violent throbbing of the temporal arteries until midnight (fourth night), [2]. ► More sleepy than
usual and tired at night (twenty-second day), [27]. ► More sleepy than usual, nevertheless can do with but four
hours sleep in the twenty-four without feeling overfatigued, [27].
► More sleepy than usual after dinner, and late at night,
when reading or writing, [27]. ►
Great drowsiness, overslept about two hours beyond the usual time; after inhalations, [27]. ► Much more drowsy,
apt to doze when sitting, and reading, or studying the Materia Medica at night which is
always a delightful occupation, keeping him awake generally till after 2 A.M. (twelfth day),
[27]. ► After
dinner, at 1 P.M., slept, and felt very sleepy till about 4 P.M. (one hundred and second
day), [16]. ►
Overpowered by sleep after dinner, for an hour (fourth day), [3].
► Very quiet sleep (first night), [6]. [460.] ►
Deep sound sleep from evening till 7 P.M. (fourth night), [3].
► Slept sounder and later than usual (eleventh day), [15]. ► Slept longer and
sounder than usual in morning (second day); sleep the same up to fifth day, [15]. ► Slept later than usual in the
morning
(fifty-sixth, fifty-seventh, fifty-eighth, and sixty-second days), [16]. ► *Can sleep
better; is more ready to get up in the morning, [25]. ► Sleeplessness. ► It
takes away the desire for sleep and the cravings of hunger; a person using it may go
forty-eight hours without sleeping or eating, [42]. ► Sleeplessness, even with such as do not take Coca in excess,
but a chronic sleeplessness with old chewers, and a leaden skin, [9]. ► Sleeplessness, but with
desire for work the whole night (sixth night), [3]. ► Loss of sleep in the evening (nineteenth day), [3]. ► Loss of sleep, with flow of
ideas at night in bed, [3]. [470.]
► After going to bed he became quite wide awake, but had
chilliness and vertigo, with fever, rush of ideas, with grief; loss of sleep till 2 A.M.,
followed by sweat and quiet sleep (eighteenth night), [3].
► Restless sleep the whole night, being awake off and on,
but without any other symptom (first day), [21]. ► Slept all night, but very restless and dreaming, and was in
all her dreams hurried, [30]. ►
During the proving, sleep somewhat disturbed, [14]. ► Disturbed sleep, with frequent waking, unpleasant dreams, and
constant perspiration, [39]. ►
Woke on back, in the midst of a dream (forty-eighth day); had had many dreams, and woke once
or twice on back (seventh, fourteenth, twenty-third, twenty-fourth, and fifty-second days);
not more dreams than usual, not so many as before (ninth and fifty-eighth days), [16]. ► Woke on back in
morning (fifth day); and many dreams (sixth and eleventh days); twice (fifty-eighth day);
woke in morning partly on back, after not so many dreams as before (tenth day), [16]. ► Second day, woke
once in night and once in the morning, lying on the back (fifty-second and sixtieth days), [16]. ► Woke three times
on back, or somewhat inclined to left side (one hundred and forty-fifth day), [16]. ► Woke two or three times at
night, or in morning on back after many dreams; tired on rising, not refreshed; this went
away after breakfast, during a walk (third day), [16].
[480.] ► Woke once or
twice in night lying on back
; from the second day, almost every night during
second, third, seventh, eighth, twelfth, thirteenth, eighteenth, and twentieth weeks, and
during fifth and sixth months of the proving, [16]. ► Woke partly on back, many dreams, a slight pain in left
deltoid (twenty-fourth day), [16]. ► Rising from bed at 11 P.M. (being unable to sleep) and going
to work, being quite awake; only now and then disturbed by pressive pain in the eyes; this
lasted till 2 A.M., and was followed by quiet sleep (third night), [3]. ► Rose more than an hour
before the usual time, read, then fell asleep in chair (one hundred and second day), [16]. ► A sleep of three
hours restored him fully from this Coca intoxication, and he could then attend to his daily
business without the least feeling of indisposition, but on the contrary with an uncommon
ease, [22]. ► Dreams.
► Many dreams (first night), [16]. ► Night dreamy, though he
slept well and awoke fresh, [12]. ► Night dreamy and restless, [12].
► All night through, incoherent dreams, not remembered, [27]. ► Dreams more than
usual, vivid, and partly suggested by what he had read lately (ninety-seventh and one
hundred and seventeenth days), [16]. [490.] ► Dreams of great
activity, [12]. ►
Sleep full of active troubled dreams, notwithstanding which awoke lively and vigorous every
morning for ten days after leaving off medicine, [12].
► Vivid dreams of fighting, suggested by reading the
“Fire Worshippers” a few days ago (seventy-third day), [16]. ► Dreamed vividly that the
medicine had caused the teeth and a piece of the jaw to become quite loose, so that one
tooth and a piece of the jaw easily came out; further dreaming connected with this
(seventy-eighth day), [16]. ►
Woke at 7 A.M., with a very vivid recollection of a dream, in which he held a beetle of the
largest kind by the upper part of the body, in the agony of death, firmly grasped between
the index finger and thumb, so that it could not hurt him, and wondered at the great power
it exercised to get loose and bite him (second day), [27].
► Dreamed of fighting for a levy with six or seven black
generals, who at last succeeded in garroting him, binding him round with ropes, preventing
his further defence, causing him great agony of mind (twelfth day), [27]. ► Dreamed he saw a recently
decreased friend hanging dead by is legs before his eyes for hours (eighth day), [27].

FEVER.

► Chilliness.
► A slight lowering of the bodily temperature, [45]. ► Chilliness (third
night), [3]. ►
About 10 P.M., when sitting indoors with a window behind my back open, chilliness, and
afterwards shivering; the shivering continued after the window was closed, and also in the
open air, going off with rather quick motion in open air. (The weather felt cold to me,
though I had on rather a thicker coat than usual; my companion felt rather cold, though
others found the evening warm at that time), (ninety-eighth day), [16]. [500.] ► Chilly (fifth day), [2].
► Felt very chilly all over, and inactive (second day), [25]. ► Felt quite cold
the whole day (seventh day), [3]. ► Chilliness in the head (seventh day), [7]. ► Heat. ► Fever in the afternoon, with great prostration, relieved by
wine (the relief continued until evening), (fifth day), [3].
► After three drachms of infusion, a feverish condition,
with increased heat of skin, [22]. ► Occasional slight heat in right chest, about middle near
sternum, indoors, 1 P.M., and afterwards (fifty-first day), [16].
► Flashes of heat up the back, and burning across abdomen
in flashes, [28]. ►
Warm feeling in front of left thigh, at 1 P.M. (ninth day), [15].
► Sweat. ►
Perspire freely and without exertion, [23]. [510.] ► Profuse sweat in the
evening (ninth day), [7]. ►
Extremely unpleasant perspiration, offensive breath, [10].

CONDITIONS.

► Aggravation.
► (Morning), Fear;
confusion of head; after rising dull headache; lachrymation, etc.; flow from nose; early, in
bed, feeling in nostril; on waking, dryness of mouth; feeling in mouth; on waking, bitter
taste; on rising, soreness at back of throat; tickling at back of throat; hawking of mucus;
on waking, pain on swallowing; at 8 o’clock, flatus from bowels; during forcible expiration,
when standing, pain in lumbar region; on waking, deadness of little finger. ► (Forenoon), Pulsation,
etc., in ears; yawning. ► (Afternoon),
About 5 or 6 o’clock, indoors, confusion of brain, etc.; headache,
etc.; about 1 o’clock, indoors, slight headache; towards 4 o’clock, while reading, pains
above eyes; bitter taste on tongue; fulness of chest, etc.; weakness; fever, etc.; at 10
o’clock, warm feeling in front of thigh. ► (Evening), Depressed, etc.; towards 9 o’clock, fulness, etc., in
forehead; flames before eyes; hearing too acute; abdomen distended; heaviness of chest,
etc.; loss of spleen; sweat. ► (Night),
Itching of pimples on thigh; chilliness; at 10 o’clock, when sitting indoors, with window
open behind back, chilliness. ► (Walking
in open air
), Vertigo; during rain, pain in temple, etc.; paroxysms of cough. ► (Ascending steps),
Vertigo; blackness before eyes. ► (Bending head forward), Giddy feeling. ►
(Blowing nose), Pain over side of head. ► (After breakfast),
Nausea. ► (Chocolate),
Colic. ► (Coffee),
Eructations; colic. ► (Coughing),
Pain in forehead. ► (After
dinner
), Eructations; sleepiness. ► (Eating), Spots before eyes; soreness in jaw. ► (Elevating head and turning eyes up),
Frontal headache. ► (Walking
quickly in hot sun
), Pain in temples. ► (Deep inspiration), Stitches in lung. ►
(Indoors), Headache; frontal headache. ► (Looking up), Headache in
temple. ► (Lying down),
Pain in top of head, etc. ► (Pressing
at stool
), Pain in forehead. ► (Raising or stretching out arm), Pain in forearm. ► (Running), At every step,
pain in occiput. ► (Shaking head
from side to side
), Pain in temple. ► (Smoking), Tickling in larynx. ►
(Stepping), While walking in open air frontal headache. ► (Stretching out fingers or grasping
anything
), Lameness in fingers. ► (After supper), Yawning. ► (Talking), Soreness in jaw; tickling in pharynx. ► (Walking), Vertigo; pain
in occiput; pain about cardiac region of stomach; pain beneath ribs; pain in instep; pain in
region of hip-joint. ► Amelioration. ► (Evening), At sunset,
frontal headache. ► (Open air),
All symptoms. ► (Walking in open
air
), Headache; frontal headache. ► (Cold beer), Colic. ► (Coffee), Sleepiness. ► (After dinner), All symptoms disappear. ►
(After eating), Headache; pain in small intestines. ► (Pressure), Pain in small
intestines. ► (Rest),
Vertigo. ► (Standing still),
Pain in temple, etc. ► (Rapid
walking
), Pain in small intestines. ► (Washing and drinking coffee), Confusion of head. ► (Wine), Vertigo.

SUPPLEMENT: COCA.

Symptom 364, in vol. iii, copied from Hering’s Monograph, begins with
“On washing;” in North. Amer. Journ. of Hom., New Series, vol. v, p. 179, first
line, it is “On waking.”


Authorities.

45, Alex.
Cochet, Journ. de Chim. Méd. (Amer. Journ. of Pharm., 1833-4), p. 58, effects of chewing,
on the Indians of Peru; (46 to 50,
Berridge’s Collections, Appendix to Brit. Journ. of Hom., general effects); 46, Dr. Martius, from Gauger’s Repert., 1842, p. 452 (Pharm.
Journ., 1843, vol. ii, p. 660); 47, Prof. Schlechtendal,
from Encyclopædia of Med. Sci. and Archiv. der Pharm., 1853 (Pharm. Journ., vol. xiii, p.
224); 48, Schroff, from Wien. Wechnbl, vol. xviii, and
Schmidt, vol. cxvi, p. 297 (New Sydenham Soc. Pub., vol. xix, p. 453), experiments with
Cocaine, its acetate and chloride, and an alcoholic extract of the leaves; 49, Rossi, Roman Correspond, Sci. (Lancet, 1866 (2), p. 195); 50, Practitioner, 1868, vol. i, p. 233, Review of Recherches
Chim. et Phys. sur l’Erythroxylum Coca du Perou et la Cocaine, by Thomas Moreno y Mais,
Paris, 1868; 51 to 55,
Edward Lippman, Thèse Étude sur la Coca du Perou, Strasbourg, 1868); 51, effects of hot infusions of 1 to 15 grams to 60 of water; 52, effects of 30 grams; 53,
extract of 2 grams; 54, obs. of Rossier, effects of
chewing 1 to 3 grams of the leaves; 55, Mr. Reis, chewed
the leaves; 56, l’Union, No. 91 (New Sydenham Soc. Pub.,
vol. xix, 455), (Berridge), effects of leaves; 57,
Scrivener, Med. Times and Gaz., 107 (2), p. 407, effects, on chewers; 58, Berridge, North. Amer. Journ. of Hom., New Series, vol. v,
1874, p. 165, Dr. David Wilson, inhaled the vapor while potentizing about 3.30 P.M.; 59, E. B. Shuttleworth, Can. Pharm. Journ., Aug., 1877 (Pharm.
Journ. and Trans., vol. viii, 1877, p. 221), effects on the Toronto Lacrosse Club.

MIND.

► Its effect is to
deaden sensation and produce even madness, [46]. ► In large quantities the chewing of leaves induces a stage of
intoxication, like that of Cannabis, [56]. ► Animation and content, [57].
► When chewed in large quantities, the Coca causes a kind
of intoxication and loss of sleep, [45]. ► The head felt agreeably light, the ideas flowed with
facility, and fantastic images followed each other in rapid succession; this was soon
succeeded by extreme drowsiness, in resisting which there was great oppression of the head
and confusion of thought. If he had given way to it the prover felt he would have passed
into an agreeable dream life, like that produced by Cannabis. The effect of the drug varies
according to the intensity of the effort made to resist it. As soon as the interference with
consciousness ceases, and the relation between the mind and the external world is
re-established, all the other functions return to their normal state, [48].

HEAD.

► Heaviness of the
head, [52]. ►
Always after chewing the leaves sleep was quiet, but the next morning there was frontal
headache, which lasted a part of the day; at the same time the tongue became coated and the
appetite impaired, [54].

EYE.

► Eyes brilliant, [57]. [520.] ► After large doses of the decoction, there is dilatation of
the pupils, and physical mental calm, [54].

EAR.

► In half an hour,
distant ringing booms through head, repeated twice, once in evening, lasting a few seconds, [58].

NOSE.

► About midnight, on
going to bed, nose felt swollen and stuffed, like an incipient catarrh (first day), [58].

FACE.

► Countenance more
animated, [57]. ►
Paleness of lips, [57]. ►
Slight yellow tinge about angles of mouth, [57].

MOUTH.

► Teeth stained
bright yellow, [57]. ►
It increases the secretion of saliva, produces a sensation of warmth and fulness in the
mouth and stomach, and stills hunger, [47]. ► Diminished saliva, [54].

THROAT.

► Some dryness of
the throat, [54]. [530.]
► Heat and dryness of the throat, [51].

STOMACH.

► It enables the
workmen to endure prolonged abstinence, [56]. ► Men may live in robust health several days without food.
Rossi, after taking a decoction of the leaves, felt neither hunger nor thirst for
forty-eight hours, [49]. ►
They appear as if they had partaken of a rich repast, [57].
► An agreeable heat; a sensation of comfort in the
epigastrium, somewhat like that produced by a glass of wine, radiating from the stomach over
the whole body, [54].

RESPIRATORY ORGANS.

►
Enables them to ascend heights without dyspnœa, [56].

PULSE.

► Pulse strong and
frequent, [57]. ►
The pulse from the first gained in frequency and strength, while the breathing lost in
frequency, but became deeper and fuller, [48]. ► Pulse 59 (before taking); 63 (after five minutes); 56 (after
fifteen minutes); 61 (after forty-five minutes), [53].

SUPERIOR EXTREMITIES.

► A
warm indistinct pain in left shoulder-joint, for a few minutes, at 12.30 P.M. (second day), [58].

GENERALITIES.

[540.] ► Tetanic convulsions, hyperæsthesia, dilated pupils, and
diminution of movements from loss of co-ordination, [50].
► Abuse of Coca causes signs of premature old age,
unsteady step, yellow skin, want of brilliancy of eye, and general indifference or apathy, [57]. ► General symptoms
like those produced by a small quantity of alcohol, a slight disturbance of vision, slight
increase in the frequency of the pulse; cold infusions produced the same effects, [51]. ► Sustains the
strength, [56]. ►
Desire for physical exertion, [57]. ► Great feeling of comfort, [48].
► More agility in walking, [57].
► Increases the bodily activity, [47]. ► The effects of small doses
seems to be to resist fatigue, which I frequently noticed in long walks, [54]. ► When provided with Coca,
they (the Peruvians) can make rapid journeys, without suffering in their respiration, and
can take unremitted exercise without being worn out by fatigue. They have been known when
acting as guides, to travel twelve or fourteen leagues without stopping, and to perform this
as rapidly as the best mounted horseman. This arises from the circumstance, that in these
elevated regions, horses soon suffer in their wind, and hence gradually relax their speed;
whilst, on the contrary, the Indians, by constantly using the Coca, do not thus suffer, and
always keep the interior of their mouth in a moist state. The inhabitants of the country
support all kinds of fatigue, for two or three days, without any other stimulant than the
coca, [45]. [550.]
► At the commencement of the match, about 1 drachm to 1
1/2 drachms of the leaves was served out to each man. This was chewed, in small portions,
during the game, the saliva being swallowed. On first taking the leaves, a sensation of heat
and dryness was produced in the throat. This was relieved by washing out the mouth, or
gargling with water, after which the desire for water was no greater than usual. Soon after
a sensible augmentation of force, and a general feeling of invigoration were realized, and
continued to be felt throughout the game, so that fatigue was wholly, or in great part
resisted. The pulse was observed to increase in frequency, perspiration was augmented, but
no mental effect was noticed, save the exhilaration of spirits always attendant on the
exercise of well-strung muscles and on the excitement of play, [59]. ► Torpor, [52]. ► General feebleness, [52]. ► It produces, in
large quantities, lassitude and drowsiness, [47]. ► The first effects are succeeded by a profound calm, a kind of
paresis, during which one does not wish to use the faculties, and is overpowered by
indolence, [49].

SKIN.

► While writing a
long letter, about 8 or 9 P.M., felt in left groin and region of abdominal ring as if the
skin were sore and smarting; it felt a little tender to touch. (Here he formerly had an
extensive glandular suppuration several years ago, from cold and fever), (first day), [58].

SLEEP.

► Slept remarkably
well last night; dreaming that something was adhering to fauces at posterior entrance to
nares which he was trying to detach; woke about 8 A.M., actually in the effort, and there
really was mucus there to detach; still has the smarting soreness (second day), [58].

FEVER.

► Increase of
subjective warmth, [48]. ►
Coldness of the extremities, [47]. ► General perspiration, [47].
[560.] ► Cutaneous
secretion rather diminished, [50].

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