CHININUM SULFURICUM.
Sulphate of quinine or chinin. Formula,
2C20H24N2O2,SH2O4+7H2O (Regnault).
Preparation for use
, Triturations.
Authorities.
1, Bohler
(Inaug. Diss., Leipsic, 1828, De Chin. Sulph.), 24 years old, effects of 1/2 to 2 grains,
repeated doses in the morning, fasting, from Journ. f. Arzneim., 2, 154; 2, N. N. took 10 grains, from ibid.; 3,
N. N., 26 years of age, took 6 grains, ibid.; 4, “a
physician,” 33 years old, took 2 grains twice with an interval of three hours, ibid.; 5, Dr. Otto Piper, 21 years old, provings with repeated doses of
1/2 grain to 12 grains, and a second proving (days noted) as follows: (first day), 1/4
grain, (third day), 1/2 grain, (fourth day), 1 grain, (seventh day), 1 grain, (thirteenth
day), 2 grains, (seventeenth day), 3 grains, Journ. f. Arznm., 2 from Piper’s MSS. of his
Inaug. Diss., with the author’s additions; 6, Leonhardi,
medical student, 23 years old, provings with (first day), 1 grain, (fourth day), 1 grain,
(fifth day), 1 grain, (ninth day), 3 grains, (seventeenth day), 4 grains, Noack’s provings,
Journ. f. Arznm., 2; 7, Laurent Fritz, provings with 1/4
grain to 6 grains, ibid.; 8, Johanna Bader, 17 1/2 years
old, not yet menstruated, but suffered lately from “menstrual leucorrhœa,”
usually excoriating, took (first day), 1 grain, (fifth day), 2 grains, (ninth day), 3
grains, (thirteenth day), 3 grains, (nineteenth day), 11 grains, (twenty-seventh day), 12
grains, (thirty-first day), 20 grains, ibid.; 9,
Friedrike Rothe, 27 years old, took 2 grains, and after some time 6 grains (had not
menstruated lately, in consequence of a “nervous fever”), ibid.; (10 to 46, selected
authorities); 10, Baldwin, effects of 8 grains in two
doses (with an interval of three hours) on a child 6 years old, N. A. J. of Hom., 8, 76
(from Southern Med. and Surg. J.); 11, ibid., effects of
68 grains in twenty-four hours, ibid.; 12, Binz, general
effects of doses over 15 grains, or of smaller doses frequently repeated, Deutsche Klinik,
1871 (Am. J. M. S., n. s., 64); 13, Binz, provings on
two sound men of 0.1 to 0.5 gramme, with special reference to urine, Virchow’s Archiv, 46,
p. 166; 14, Blande, Journ. f. Arznm., 2, effects of 24
grains in twenty-four hours; 15, Dictionnaire de Méd.,
18, 132, effects of 5 to 6 grains on a man, Journ. f. Arznm., 2; 16,
Dr. Elson, experiments with 2 to 20 grains, effect on pulse, Am. J. M. S., n. s., 52, 97; 17, Favier, took 18 grammes in ten days, Inaug. Thesis,
Montpellier, 1848 (from Wenz, Monograph on Chinin, p. 126); 18,
Garraway, effects of large doses on a women aged 40 Br. Med. J., 1869; 19, Giaconini, a nurse, in a fit of melancholia, took 3 drachms
at once, Omod. Ann. di Med., 1841 (S. J., 33, 24); 20,
ibid., a man took 12 to 15 grammes by mistake, ibid.; 21,
Giaconini, Traité Expérimental de Mat. Méd., took 3 to 4 grammes every evening (Wenz’s
Monograph); 22, Garraway, toxic action of 1 grain, Br.
Med. J., 1870; 23, v. Graefe, in Clapton on Quinine, St.
Thos. Hosp. Rep., 1870, effects of half-drachm doses continued for some time (in all, 6
drachms); 24, Hirscher, effects of 1 grain every two
hours, Journ. f. Arznm., 2; 25, Henning, effects of
about 1 grain on a convalescing patient, Br. Med. Journ., 1869; 26,
Prof. Ith, effects of several doses of 3 to 4 grains, Journ. f. Arznm., 2; 27, Kremers, effects of 20 grains on a young man aged 25, Journ.
f. Arznm., 2; 28, Kremers himself took 20 grains, ibid.;
29, Lembert, Essai sur la Méthode Endermique, p. 97; 30, Lieber, effects in inunction (by means of a blister), Journ.
f. Arznm., 2; 31, Kreuser, effects on workers in Chinin
factory (from Wenz’s Monograph); 32, Meniere, general
statement, from Trousseau and Pidoux, Traité de Thérap.; 33,
Mutzer, general statement, Journ. f. Arznm., 2; 34,
Perrine, experiments on pulse with doses of 8 grains a day for several days (Journ. f. Arz.,
2, “from Phil. Journ., No. 7, 1828”); 35,
Vicol and Mossop, effects of 5 and of 10 grains, as observed by ophthalmoscope, B. and F.
Med.-Chir. Rev., 1872; 36, Ranke, provings, on self and
two others (10 and 20-grain doses), Med. Times and Gaz., 1857; 37,
Ringer and Gell, influence on temperature of body in health, a boy took 10 grains on three
occasions, girl took five doses in six days (8 to 20 grains), Lancet, Oct. 1868; 38, M. Scott, effect of 2 grains three times a day, increasing a
grain each day to 20 grains a day, Lond. Med. and Phys. J., 1833; 39,
Sistach, effects on uterus, Gaz. de Paris, 1874; 40,
Skinner, effects of 1/4 of a grain on a delicate young woman, Br. Med. J., 1870; 41, Whittmann, effects of 6 grains on a man aged 24, Journ. f.
Arznm., 2; 42, ibid., effects of 4 grains on a man of
18, ibid.; 43, ibid., effects of 6 grains, repeated to
24 grains in twenty-four hours, on a man of 20, ibid.; 44,
tox. by med. dose, Phil. Med. Times, 1, 446, 1871; 45,
Chevallier, general effects on workers in Chinin factories, N. Am. J. Hom., 5, 265; 46, Dr. W. H. Burt, provings, (first day), 2 grains, (second
day), 4 grains, (third day), 10 grains, Monograph on Cinchona; 47,
J. C. P., one dose, 5 grains, ibid.; 48, Berridge,
proving with 200th dil., one dose, N. Y. Journ. of Hom., 2, 461; 49,
J. C. Morgan, provings, 3d dec. trit., as follows: first day, morning and evening; second
day, morning and evening; third day, evening; fourth day, evening; sixth day, 3 A.M. and
evening; seventh day, evening; ninth day, evening; tenth day, noon and evening; twelfth day,
evening; thirteenth day, morning; fourteenth day, morning. Took crude drug as follows:
fourteenth day, 1/2 grain, noon and night; fifteenth day, 1/2 grain, morning and evening;
sixteenth day, 1/2 grain, morning and evening; seventeenth day, 1 grain, morning; nineteenth
day, 2 1/2 grains; twentieth day, 4 grains, at noon and 6 P.M. Took 200th dil. as follows;
twenty-fourth day four doses, twenty-fifth day four doses, twenty-sixth day, one dose, Am.
J. of Hom. Mat. Med., 8, 325; 50, Dr. Cachere,
hæmaturia caused by Quinine administered in intermittent fever, New Orleans Journ. of Med.,
Oct. 1869; [Departure from strict “purity” seems in this case admissible; the
details were obtained from the original by Dr. Holcombe.] 51,
Jerusalimsky (of Moscow), Monograph on Chinin, 1875, a woman, aged 20, took 10 grains, and
afterward 6 grains, to observe effect on pulse, etc.; 52,
ibid., a woman, aged 27, perfectly well, made three experiments with 5, 10, and 10 grains; 53, ibid., another woman, aged 26, made three experiments with
same doses; 54, Bohn, effects of 0.25 gramme, three
times a day for twenty days, N. Z. f. H. K., 1870.
MIND.
► Emotional. ► Excited, [52]. ► Sensation as though he were intoxicated, though his mental
powers were perfect, [27]. ►
An intoxicated sensation, changing to a heaviness of the head (fifth day), [5]. ► Uncommonly lively mood
(ninth day), [8]. ►
An extremely lively mood and an activity returned about 9 P.M., only after a walk in the
open air (eighth day), [6]. ►
Buoyant feeling in the evening (twelfth day), [49]. ► Rather more vim and buoyancy than usual, during the evening
especially (second day), [49]. ►
Feeling of considerable mental resolution, with shrinking from taking much trouble about
matters, evening (twenty-sixth day), [49]. ► Found my will positive in insisting on professional orders,
but self-restrained and deliberate, in the forenoon (seventeenth day), [49]. [10.] ►
Awoke at midnight with long-continued cries; he knew that he was crying, but could not help
it; he was obliged to get out of bed; he wrapped himself in the clothes, and remained
sitting; after a few minutes he came to himself again, and soon fell asleep (sixth day), [5]. ► Great depression
of spirits (fourteenth day), [5]. ► Great depression of spirits and fretfulness (eleventh day), [7]. ► *Despondency,
[5]. ► During much
of the proving the morale has been one of will, with little courage, or hope, or
contentment, which, however, I am not prepared to attribute to the drug with confidence
(twenty-seventh day), [49]. ►
Anxiety (after two hours), [2]. ►
Great anxiety, amounting to an apprehension, as if some evil would happen (fifth day), [7]. ► Attacks of anxiety
(third day), [6]. ►
Feeling of anxiety, which at times obliges him to leave the bed (third and fourth nights), [7]. ► Anxious and
sleepless during the night, [27]. [20.] ► The day being clear
and windy, and a holiday to many, few people being on the street produced a sort of
street-quietness; felt a gloom come over me, *as if some evil were
impending; relieved by a specific trust in the Alminghty; this from 3 to 4.15
P.M. (first day), [49]. ►
*Recurrence of feeling of impending evil, in the afternoon (sixth day), [49].
► Ill-humored and fretful (ninth day), [6]. ► After sleep, readily
angered, even by a cold draft on my legs (fortieth day), [49].
► Intellectual. ►
The morale, from the first, has resembled the physical symptoms, dull feelings in both
coexisting; in both simultaneously sharpness, the former in the beginning, the latter at
present (twentieth day), [49]. ►
Thought difficult, while writing (fifth day), [5]. ► Great disinclination to mental labor (eighth day), [5]. ► Averse to difficult study or other work (twelfth day), [49]. ► At 12 P.M., some
repugnance to the prospective burden of to-morrow’s business (having partaken of vegetable
soup, an orange taken after that); then at 12.25 took another powder; then, leaning over my
table, tasted the food (second day), [49]. ► 4.30 P.M., whilst writing, was interrupted; decided feeling
to “cut it short” (first day), [49]. [30.] ► Wrote
“right” instead of “left” by mistake (twenty-eighth day), [49]. ► Wrote the word
“left” instead of “right,” afternoon (twenty-sixth day), [49]. ► Wrote the word
“left” instead of “right;” have made a number of similar mistakes in
talking during the past few days, in the evening (fourteenth day), [49]. ► Again I mistakenly wrote
at first “left” instead of “right” (I remember a report I published some
time ago of contusion of the spine cured by Hypericum,
in which the same error occurs; I do not remember whether I had then taken any medicine;
possibly I had taken China or some other), (fifteenth
day), [49]. ►
Memory “all muddled,” [46]. ► Lost the power of naming substantives; was obliged for a long
while to consider what different familiar things were called; and as to casting up a line of
six or eight figures correctly, it was utterly impossible; he could never make the amount
twice alike; his perceptions of quantity were greatly impaired, so that in prescriptions he
wrote ounces instead of drachms, ordered drachms instead of grains, directed draughts to be
put in gallipots, and prescribed fluids to be made into pills (14 to 16 grains daily), [38].
HEAD.
► Confusion and Vertigo.
► Confusion of the head (fifth and twentieth days), [5]. ► Vertigo, [19], [20]; (after one
hour and a quarter), [27]. ►
Vertigo, on stooping (twenty-first day), [7]. ► Vertigo and whirling in the head (twenty-ninth day), [8]. [40.] ► Vertigo and palpitation (after four hours), [51]. ►► *Whirling in the head,
like a “millwheel” (thirty-first day), [8].
► General Head. ►
In morning, whole head swollen, and the face so altered that she could with great difficulty
open her mouth for food, [44]. ►
Rush of blood to the head, [1], [54]. ► Rush of blood to the head,
towards evening, [4]. ►
Chronic disturbance of brain, [12]. ► Head stupefied, and especially painful in the left temple
(twenty-sixth day), [7]. ►
Head empty, in the morning, [7]. ►
Light, hollow feeling in head, [46]. ► Heaviness in the head (seventh day), [5]. [50.] ►
Heaviness and confusion of the head continue until going to sleep in the evening (seventh
day), [5]. ► Heavy
feeling in head, especially the top, in the evening (twenty-seventh day), [49]. ► Heavy feeling in the head
is notable; sitting after stool with protrusion; the room being somewhat warm, the day
stormy. ► It is not unlike the inertia of the muscles of
the legs in walking before mentioned; it is also attended by a sense of vascular tension and
fulness and dry heat, fingers and feet cold; the head feels much better by application of my
cold hand on the top, in the forenoon (twenty-eighth day), [49].
► Pain in the head (after one hour), [19]. ► Very violent pain in the
head, on rising in the morning, especially noticed on stooping or moving (twenty-ninth day),
[7]. ► Such fulness
in the head that he was unable to walk, [27]. ► Sudden fulness of head (head leaning to left), especially the
left side and top, after writing, in the forenoon (twentieth day), [49]. ► Head feels full while
sitting writing, in forenoon (twenty-eighth day), [49].
► A moderate excitement caused a marked feeling of dull
tension (not a rare symptom) about the head, especially at the sides; settling on the top as
a pressure, extending later to the “perceptive region” of the forehead, at last
completing the circuit to occiput like a rim, in the morning (twenty-third day), [49]. ► Headache, [1], [5]; (tenth day),
[6]. [60.] ► Headache (boy, after twenty-five minutes, lasted five
minutes); (girl, from 8 grains, began in one hundred and seventy minutes; from 10 grains, in
one hundred and seventy-five minutes; from 12 grains, in ninety-five minutes; from 20
grains, in thirty minutes; from 20 grains, in fifteen minutes), [37]. ► Headache, extending to the
temples, in the afternoon, and was somewhat relieved towards evening (eighteenth day), [6]. ► Headache after
walking a long time in the sun, in the afternoon (seventh day), [8]. ► Headache at 3 A.M., with
violent pressive pains in the occiput, which only disappear on rising (second day), [4]. ► Headache at 7
P.M., commencing in the forehead, and at last extending to the occiput, lasting an hour
(thirteenth day), [5]. ►
Headache, with vertigo and loss of consciousness, [5].
► Very severe headache, worse towards evening, with
violent palpitation of the arteries of the head, as if the head would be torn asunder, with
glowing heat of the face, vertigo, at times ringing and roaring in the ears, [1]. ► Violent headache, which
disappeared after eight to twelve days, [14]. ► Violent headache in the forenoon, more especially in the left
side, with frequent pulsation of the temporal arteries, with excitement through the whole
body (twelfth day), [7]. ►
Dull headache (fourteenth day), [6]. [70.] ► The headache and fever
were relieved on walking in the open air, with appearance of slight sweat (thirty-first
day), [6]. ► I rose
and bent over my table; then throbbing in the head and shoulders; forgot it on going out
(first day), [49]. ►
Forehead. ► About 4 P.M., the frontal arteries
began to pulsate, the heat of the face increased to redness, and continued; especially was
it the most intense about the eyes (seventh day), [5].
► Pain in the forehead, [9];
(twenty-second day), [5]. ►
Pain in the forehead after dinner (seventh day), [5]. ► Pain in the forehead between 5 and 6 P.M. (third and fourth
days), [7]. ► Pain
in the forehead and temples appeared towards evening, and gradually increased in intensity,
with visible pulsation of the temporal arteries, heat of the head, and ringing in the ears
(fourth day), [7]. ►
Some pain in the forehead in the afternoon (fifth day), [6].
► Some pain in the forehead about 4 P.M. (second day), [5]. ► Much pain in the
forehead and temples (eighth day), [7]. [80.] ► Violent pain in the
forehead, lasting twenty-four hours (after four hours), [7].
► Violent pain in the forehead two hours after 2 grains;
it disappeared in the course of the afternoon (fifth day), [8].
► Extremely violent pain in the left side of the
forehead, with vertigo, ringing in the ears, and weakness as from long illness, at 9 A.M.
(eighteenth day), [7]. ►
Frontal headache from 1 to 4 P.M. (thirty-first day), [6].
► Slight frontal headache, lasting all day, and becoming
worse towards evening, [3]. ►
Violent frontal headache on waking (twenty-third day), [5].
► Violent frontal headache in the evening (fifth day), [5]. ► Severe frontal
headache, worse on the left side, on rising in the morning, becoming somewhat less during
the forenoon, but succeeded by confusion of the head the whole day; it was again worse at 5
P.M., without any general excitement (nineteenth day), [5].
► Dull frontal headache (twenty-fourth day), [5]. ► Headache in the
forehead and left temple (thirteenth day), [8]. [90.] ► Dull headache
extending from the temples to the middle of the forehead, in the afternoon (eight day), [6]. ► Drawing headache,
extending from the temples to the middle of the forehead (twenty-seventh day), [6]. ► Pressive pain in
the forehead and orbits, aggravated by moving the eyes or turning the head, [5]. ► Sudden boring-sticking in
left centre of forehead; spot like the end of the little finger, in the evening
(twenty-fifth day), [49]. ►
Tearing and drawing in the forehead and left temple (twenty-third day), [8]. ► Temples. ► Temporal arteries and veins of hands seem quite full, evening
(twenty-sixth day), [49]. ►
Repeated twitching of fibres of temporal muscles above left zygoma, in the afternoon
(twenty-fourth day), [49]. ►
Violent pains in the left temple; the pain extends to the eyebrow, and obliges him to lie
down, with which he seeks a cool place on the sofa in order to relieve the pain (first day),
[7]. ► Violent
headache in the temples, towards evening (twenty-ninth day), [6].
► Dull pressing pain in the temples (twenty-seventh day),
[5]. [100.]
► Sitting at table, leaned to right, neuralgic sensation
shot up the anterior left temple (forty-second day), [49].
► Vertex. ►
Reading, bent forward, steady neuralgic pain from the right supra-orbital foramen, straight
up to vertex, in a narrow line, ceased after sitting up straight, in the night (twentieth
day), [49]. ►
Parietals. ► Dull neuralgia, left parietal
region, then right vertex, in the evening (twenty-fourth day), [49]. ► On raising the eyebrows,
neuralgic pain from outer right brow up that side of the head; then a slight twinge in outer
end of left eyebrow, early in morning (nineteenth day), [49].
► Left side of head and throat feel as if they would ache
(not rare), in the afternoon (third day), [49]. ► Whilst writing, with head inclined to left, dull headache on
the right side (after five minutes); I have the like sometimes from constipation or from
mechanical tension of the right cervical muscles (twelfth day), [49]. ► Whilst writing, dull ache,
right side, extending as a sharp neuralgic sensation to right outer brow, and dull, later,
to right mastoid process, returning slightly to brow, and up temporal ridge, same side;
again in ear, right side, then back to brow; later, a catch in middle of right
sterno-mastoid muscle, when turning head that way, after midnight (seventeenth day), [49]. ► Whilst writing,
with head inclined to left side, dull headache on left side (similar to early symptoms),
extends to left side of neck and throat, and right mastoid process, then to vertex, then to
occiput; shifting, then to brows (varying with position of head), now pressing in both
temples, extending over coronal suture, in the morning (twenty-first day), [49]. ► Slight dull headache,
right side (old symptom since an attack of fever, with misapplied water-cure, in 1860, in
Illinois), in the afternoon (fourteenth day), [49]. ► Whilst standing holding my head down, a little dull stitch in
upper left parietal, felt also to root of nose, left side (soon), (fifteenth day), [49]. [110.] ► On suddenly rising to a standing posture, a quick stitch in
left upper parietal region (soon), (fourteenth day), [49].
► Walking in open air, neuralgic twinge, right side of
head, lingering some time in upper right temple, in the evening (eighteenth day), [49]. ► Sitting, sudden
neuralgic twinge in right side of head, from brow to lambdoidal suture, in the evening
(eighteenth day), [49]. ►
When about to dine, and whilst standing, return of the twinge from outer right brow to
lambdoidal suture, i. e., above temporal ridge
(nineteenth day), [49]. ►
On going out with head down, sharp neuralgic twinge in and behind left parietal
protuberance, in the afternoon (twentieth day), [49]. ► Occiput. ► Threatening
of dull headache, left occiput, in the evening (nineteenth day), [49]. ► Dull twinges, left
occipital protuberance, becoming a steady ache for a short time, in the afternoon
(twenty-fourth day), [49]. ►
On holding up head suddenly to right, a little shock across lower occiput, in the evening
(fifteenth day), [49]. ►
External Head. ► Dandruff in large amount also
falls when scratching the scalp, attended by relief; also similar conditions in the beard on
the chin, especially left side, in the evening (twenty-fourth day), [49]. ► Prickling in the forehead,
with confusion of the same (seventh day), [6]. [120.] ► Recurrence of itching
of scalp here and there, coming and going, in the evening (twenty-fourth day), [49]. ► Whilst writing,
itching above edge of frontal hair, right and left sides, then below right zygoma, then
right side of top of head, then left vertex, right chin, left post-mastoid surface, inner
left eyebrow, etc. (twenty-first day), [49]. ► Itching in vertex and occiput, left side (twenty-first day), [49].® 2000
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