Antipyrinum.
Phenazon (Phenyl-dimethyl-pyrazolon). C11 H12 N2O. A product of coal tar through toluin. Solution
and trituration.Clinical.─
Dysmenia. Enuresis. Epilepsy.
Epistaxis. Erythema. German measles. Headache. Heart, paralysis of. Mind, deranged.
Respiration, Cheyne-Stokes. Scarlatina. Throat, sore. Toothache. Urticaria.
Characteristics.─
Antipyrine
is known from the poisonous effects it has produced in old-school practice. Many fatal cases
have been recorded, and there can be little doubt that its injudicious use has determined a
fatal issue in many cases that have remained unrecorded. Its action is very like that of Antifebrin in producing collapse, but it has more effect on the
skin, causing scarlet rash and œdema. A young lady patient of mine who took Antipyrin on her own account, whenever she thought she might be
going to have a headache, developed intense dysmenorrhœa (to which she was not subject),
with depression. This was only removed after she had discontinued the drug. Later on she
took Phenacetin, with the result that an eruption of
erythema appeared on both cheeks, which peeled after a few days, and recurred persistently.
It would seem from the above that the drug is homœopathic to some forms, at least, of
neuralgia. One patient had Cheyne-Stokes respiration. Erythema appears first on face and
arms, last on legs. Hansen mentions its use in enuresis and epistaxis. > Hot drinks.
Relations.─
Compare:
Anilinum (skin). Antefeb.; Ars.; Chloral; Acon. (numbness; rapidity of attack). Antidoted by: Bell. The symptoms are much intensified in persons
addicted to coffee in excess.
SYMPTOMS.
1. Mind.─
Loss of consciousness.─Fear
of impending insanity (mental balance did not return for some months).─Excitement.─Continual
crying.─Nervous anxiety.
2. Head.─
Headache, with toothache; pain behind
both ears of tearing character.─Snapping sensation in head.
3. Eyes.─
Complete loss of vision.─Eyelids
swollen so that eyes were almost closed.─Coryza.
4. Ears.─
Buzzing in ears.
5. Nose.─
Tingling burning in nose, with sneezing
and running from eyes and nose; nose and face swollen.─Coppery smell
which comes and goes.
6. Face.─
Œdema; dusky red face.
7. Teeth.─
General toothache, together with
headache; pain behind both ears of a tearing character.
8. Mouth.─
Tingling burning in gums, mouth, and
throat.─Lump in mouth about an inch thick just below level of upper
teeth (passed away in half-hour).
9. Throat.─
Dryness, burning, swelling, l. side of
throat with aphonia; l. tonsil white and swollen.─Tight, constricted
feeling.
11. Stomach.─
Attacks of excitement accompanied by
vomiting (in a child).─Epigastric pain, causing to bend double and cry
out.─Expanding sensation rising from stomach.
14. Urinary Organs.─
Incontinence of urine.─Amount
diminished.
17. Respiratory Organs.─
Cheyne-Stokes breathing.─Hoarseness
following aphonia.
18. Chest.─
Sensation as though contents of thorax
and abdomen were being forcibly drawn up towards throat, and r. testicle to abdomen.─Dyspnœa;
tightness of chest.─Sensation of tumour over notch of sternum.─Inability
to lie down.
19. Heart.─
Pulse feeble and rapid.─Fainting
spells.
20. Neck and Back.─
Feeling of numberless pins
pricking him down each side of neck.
21. Limbs.─
Pains in limbs.─Limbs
swollen.
22. Upper Limbs.─
Cramp in r. arm.─Fingers
of r. hand clenched in the form of a claw.
24. Generalities.─
Feeling of numberless pins
pricking him down each side of the neck, extending down r. chest and abdomen, particularly
severe r. side of scrotum and r. testicle, also in legs and feet, severely r., slightly l.─Sensation
as if contents of chest and abdomen drawn upwards, felt he was “drawn in a ruck,”
and, being unable to stand, fell on the floor.─Trembled violently all
over, had cramp in r. arm.─Epileptic attacks, with partial unilateral
twitching; contraction of muscles; chattering of teeth; jactitation.─Cyanosis.─Collapse.─Throbbing
all over body.─Sensation as if inside of body were filled with ice.
25. Skin.─
Rash, erythema or urticaria, with
troublesome itching; chiefly between fingers.─Irregular rounded pimples
lying close together, in some places confluent, forming patches, between which skin was
normal, giving a marbled appearance, lasted five days, turned brownish and desquamated
slightly.─Eruption thickest on body and extremities, extensor more
covered than flexor surfaces.─Eruption begins on face and arms, last on
legs.─Scarlet macular eruption.
27. Fever.─
Excessive perspiration.─Throbbing
all over body, coldness of hands and feet, nervous shuddering without chill.─Pulse
goes up and down with the temperature.® 2000
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