COLCHICINUM.
Alkaloid from Colchicum autumnale; Formula, C17H19NO5.
Preparation
, Triturations.
Authorities.
1, Schroff’s
provings, Œst. Zeit. f. Pract. Heilk., 1856, 22-24, Heinrich took .01 of a gramme, and
after a week took .02 gramme; 2, the only case of
poisoning known, Ber. Rudolph-stift, 227, 1867, a woman, aged twenty, took a solution of 45
milligrammes (Husemann’s Pflanzenstoffe, 498).
EYE.
► Pupils widely
dilated, [2].
FACE.
► Tearing pains in
the face, [2].
MOUTH.
► Increased
secretion of saliva, [1].
STOMACH.
► Eructation.
► Eructations, nausea, and great desire to vomit, [1]. ► Nausea and Vomiting.
► Slight nausea, and an uncomfortable sensation, which
distracted the attention of the prover from the lecture to which he was listening, [1]. ► On rising from
bed, at night, nausea suddenly increased, and was followed by vomiting of undigested food,
and afterwards of a bitter greenish fluid; the vomiting was repeated early in the morning, [1]. ► Vomiting of
greenish substances, frequently repeated, [2]. ► Vomiting of blood for nine or ten days, [2]. ► Stomach. ► Pains in epigastric region (after four hours), [2]. [10.] ►
Excessive sensitiveness of epigastric region, [2].
ABDOMEN.
► Distension and
sensitiveness in the abdomen, [1]. ► Frequent rumbling in the bowels, [1].
RECTUM AND ANUS.
► Urging
to stool, causing him to leave his bed, followed by copious pasty evacuation, with excessive
tenesmus; this was repeated three times within a short period, [1].
STOOL.
► Two stools on the
second day, one on the third day, three on the fourth day, all accompanied by tenesmus, and
consisting of a thin fluid with numerous flakes, looking like the cooked white or an egg, in
pieces from two to four lines long, [1]. ► Stools thin, yellowish-green, and slimy, accompanied by pain
(second day), [1]. ►
Liquid stools, [2].
URINARY ORGANS.
► Urine
turbid, depositing a copious white sediment, [1].
HEART AND PULSE.
► Pulse
96, [2]. ► Pulse
during the first two hours gradually sank about eleven beats, [1].
SUPERIOR EXTREMITIES.
[20.]
► Convulsive jerkings of right hand, [2].
GENERAL SYMPTOMS.
► Very
great exhaustion on the second day after taking Colchicin, increased to a feverish
excitement, lasting for two days, so that he was obliged to keep his bed on the second day, [1].
SLEEP AND DREAMS.
► Slight
somnolency and collapse, [2]. ►
Awakened from sleep soon after midnight by uneasy dreams, [1].
FEVER.
► The fever appeared
as a chill about noon on the first day, followed by violent heat, lasting several hours,
with increased thirst, very rapid pulse, confusion of the head, uneasiness, and
sleeplessness, [1].® 2000
Article