COFFEINUM.
Alkaloid obtained from Coffea Arabica. Formula, C8H10N4O2.
Preparation
, Triturations.
Authorities.
1, Dr. C. G.
Lehman, effects on students of doses of 2 to 10 grains, from Brill’s monograph on C.; 2, Dr. Frerichs took 25 grains, from the same; 3, Dr. J. Lehman (see No. 12, under Coffea tosta), effects of 4
to 6-grain doses; 4, Eustratiades, Thèse de Paris,
1870, conclusions from series of examinations of urine. (See also sphygmographic tracing,
Plate II, Fig. 11 to 22, from 5 Marvaud, Aliments d’Épargne).
MIND.
► Emotional. ► Great excitement, so that he was unable to fix the mind, [2]. ► Very excited
fantasies, [3]. ►
Peculiar intoxicated condition, [3]. ► Delirium, [1]. ► Visions, [3]. ► Intellectual. ►
Confusion of ideas, [3]. ►
Obscuration of mind, [1].
HEAD.
► Slight vertigo, [2]. ► Pulsation of the
arteries on the head and temples very marked, [2]. [10.] ► Head heavy and
confused, [2]. ►
Headache, [1].
EYE.
► Vision of sparks, [1].
EAR.
► Roaring in the ears,
[1], [2].
STOMACH.
► Vomiting, with
relief of all the symptoms (after one hour), [2].
URINARY ORGANS.
► Urethra.
► Constant urging to urinate, but only very scanty
discharge, [3]. ►
Micturition. ► Amount of urine increased 140
c.c.; urea diminished 2.9 grammes; phosphoric acid diminished 0.2 grammes; sodium chloride
diminished 0.9 grammes, [3]. ►
Amount of urine increased 4.84 c.c.; urea diminished 3.1 grammes; phosphoric acid diminished
0.37 grammes; sodium chloride increased 0.1 grammes, [3].
► Urine. ►
Increase of urea during first twenty-four hours, [1]. ► First, Coffeine lessens the quantity of urea excreted, to a
remarkable degree; diminution of 14.100 grammes the first week, from 15 centigrammes
Coffeine; of 28.100 grammes, the second week, from 30 centigrammes. This diminution begins
from the first day of taking Coffeine. On the subsequent days it is greater than at first,
but is not afterwards increased (no cumulative action in the system, as in the case of
Digitalin), [4].
SEXUAL ORGANS.
[20.] ► Erections, [1].
CHEST.
► Oppression of the
chest, [1].
HEART AND PULSE.
►
Palpitation, [1]. ►
Pulse very rapid, [3]. ►
Extremely frequent, irregular, and often intermitting pulse, [1].
► Pulse full and hard, rising from 70 to 80, in fifteen
minutes, [2]. ► On
considering the changes in the pulse under the action of Coffeine,
they are seen to be very similar to those observed after drinking a decoction of raw coffee;
only they are, as might be expected, more strongly marked, [5].
GENERAL SYMPTOMS.
► Great
excitement of the nervous and vascular systems, [1]. ► Trembling, [3]. ► Great uneasiness, [2].
SLEEP.
[30.] ► At last very sound sleep, [3].
► Loss of sleep, [1].
CONDITIONS.
► Amelioration.
► (Vomiting), All
symptoms.
SUPPLEMENT: COFFEINUM.
Authority.
5, Dr. Kelp,
Memorab., 22, 1877 (S. J., 176, 220), a woman took two powders of the citrate, each
containing 0.24 gram.►
She was seized with remarkable restlessness and dizziness,
and could not keep erect. Violent præcordial anxiety, palpitation. Abdominal pulsation.
Violent trembling of all the extremities. Grating of the teeth. Features expressive of the
greatest anxiety. Feeling of constriction of the neck and throat, recurring periodically
every fifteen minutes. Pulse very rapid. This condition lasted three hours, and gradually
disappeared, [5].® 2000
Article